Why some individuals experience alcohol withdrawal symptoms? Removing alcohol from diets can cause withdrawal symptoms in people who have harmful drinking habits. The symptoms could become severe or sometimes dangerous, but why? This new study may answer this question.

An estimated 16 million people, including both adults and adolescents, in the United States alone, have Alcohol use disorder. It negatively affects an individual’s overall state of health and quality of life.

Previous research has shown the link of alcohol use disorder with inherited genetic traits, stating that genetic determines about half of the risk of developing alcohol use disorder.

Symptoms of alcohol withdrawal syndrome include headaches, tremors, hypertension, nausea, agitation, and sometimes even seizures.

Experts from the Yale School of Medicine at Yale University in New Haven, CT, along with colleagues from Aarhus University in Denmark, and from other international institutions have explored the facts behind this set of symptoms.

Their findings were published in Alcoholism: Clinical and Experimental Research.

In their research, they found that certain variants in the SORCS2 gene predict the severity of withdrawal symptoms. According to them, SORCS2 variants may disrupt stress-regulatory mechanisms in the hippocampus, a complex brain structure involved in the reward system, which also mediates addiction.

“Better understanding of the many genes likely to be involved in withdrawal symptoms could ultimately lead to new medications that moderate these symptoms, which could help with the discontinuation of habitual alcohol use,” said senior author, Prof. Joel Gelernter.




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